Kondo, T. et al., “Intraoperative Radiotherapy Combined with Posterior Decompression and Stabilization for Non-Ambulatory Paralytic Patients due to Spinal Metastasis.” (2008)

Treatment Use

Electron IORT

Cancer Indication

Spinal Metastases

Number of Patients

107

Summary/Conclusion

IORT for spinal cord compression caused by metastatic spinal tumors achieved a good post-operative ambulatory rate (80%) regardless of the cancer type or presence or absence of previous EBRT, thereby revealing its usefulness.

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Williams, C.P. et al., “Clinical Results of Intraoperative Radiation Therapy for Patients with Locally Recurrent and Advanced Tumors Having Colorectal Involvement.” (2008)

Treatment Use

Mobetron

Cancer Indication

Colorectal

Number of Patients

40

Summary/Conclusion

The introduction of IORT has allowed a selective treatment approach to locally advanced primary and recurrent neoplasms, which traditionally would have been deemed unresectable. Using IORT, extended resections may be avoided in selected high risk patients with low risk of local recurrence and minimal morbidity.

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Gillis, A. et al. “Long-term Outcomes and Toxicities of Intraoperative Radiotherapy for High-Risk Neuroblastoma.” (2007)

Treatment Use

Mobetron

Cancer Indication

Pediatric

Number of Patients

31

Summary/Conclusion

IORT at the time of primary resection offers effective local control in patients with high-risk neuroblastoma. Compared to historical controls, IORT achieved comparable control and survival rates while avoiding many side effects associated with external beam radiotherapy in young children.

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