2014 SICPRE Congress Best Abstracts – Aesthetic Evaluation in Oncoplastic and Conservative Breast Surgery: A Comparative Analysis

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

107

Summary/Conclusion

Background In conservative breast surgery, the achievement of a satisfactory cosmetic result could be challenging; oncoplastic techniques may be helpful in many cases. A comparative analysis was performed among 3 groups of patients undergoing oncoplastic techniques plus external radiation therapy or intraoperative radiotherapy (IORT) and breast conservative surgery plus external radiation therapy; long-term oncologic results … Continued

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Phillippson, C. et al., “Early Invasive Cancer and Partial Intraoperative Electron Radiation Therapy of the Breast: Experience of the Jules Bordet Institute.” (2014)

Treatment Use

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

200

Summary/Conclusion

The preoperative diagnostic work-up must be comprehensive and the selection process must be rigorous for this therapeutic approach reserved for small ductal unifocal cancers. After 23.3 months median follow-up, the clinical results of IOERT for selected patients are encouraging for locoregional recurrence rate and toxicity rates. The satisfaction of our patients in terms of quality of life was extremely high.

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Veronesi, U. et al., “Intraoperative Radiotherapy Versus External Radiotherapy for Early Breast Cancer (ELIOT): a Randomized Controlled Evidence Trial.” (2013)

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1305

Summary/Conclusion

Although the rate of IBTR was within pre-specified equivalence margin, the rate was significantly greater than with EBRT, and overall survival did not differ between the groups. Improved selection of patients should reduce the rate of IBTR with IOERT.

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Leonardi, M.C. et al., “How do the ASTRO Consensus Statement Guidelines for the Application of Accelerated Partial Breast Irradiation Fit Intraoperative Radiotherapy? A Retrospective Analysis of Patients Treated at the European Institute of Oncology.” (2012)

Treatment Use

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1822

Summary/Conclusion

The 5-year rate of ipsilateral breast recurrence for ASTRO suitable, cautionary and unsuitable groups were 1.5%, 4.4% and 8.8% (p = 0.0003)…the ASTRO recommendations offer useful guidance to judge the appropriateness of APBI using ELIOT.

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