Breast cancer electron intraoperative radiotherapy: assessment of preoperative selection factors from a retrospective analysis of 758 patients and review of literature

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

758

Summary/Conclusion

Objective To report our experience with full-dose 21 Gy IORT in early breast cancer patients after breast-conserving surgery to define most important selection factors. Methods Seven hundred and fifty eight patients, subjected to conserving surgery and IORT, were retrospectively analyzed evaluating most important clinical outcomes. Results Median follow up was 5.2 years. Results from Cox analyses defined … Continued

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The Role of Intraoperative Radiation Therapy in the Management of Recurrent and Locally Advanced Gynecologic Cancers

Treatment Use

Electron IORT

Cancer Indication

Gynecological

Number of Patients

Summary/Conclusion

Abstract For patients with locally advanced primary or recurrent gynecologic cancers, prognosis is poor. doses of external beam radiation therapy required to treat either gross or microscopic disease in patients previously irradiated or treated surgically surgically exceed doses that are tolerated by normal anatomic structures. Intraoperative radiation therapy allows maximal tumor control achievable with radiation … Continued

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Intraoperative Radiotherapy in the Era of Intensive Neoadjuvant Chemotherapy and Chemoradiotherapy for Pancreatic Adenocarcinoma

Treatment Use

Electron IORT

Cancer Indication

Pancreatic

Number of Patients

68

Summary/Conclusion

Objectives Improved outcomes with FOLFIRINOX or gemcitabine with nab-paclitaxel in the treatment of metastatic pancreatic adenocarcinoma (PDAC) have prompted incorporation of these regimens into neoadjuvant treatment of locally advanced unresectable PDAC. Whereas some patients remain unresectable on surgical exploration, others are able to undergo resection after intensive neoadjuvant treatment. We evaluated outcomes and toxicity associated … Continued

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Results of a pooled analysis of IOERT containing multimodality treatment for locally recurrent rectal cancer: Results of 565 patients of two major treatment centers

Treatment Use

Electron IORT

Cancer Indication

Colorectal

Number of Patients

565

Summary/Conclusion

Objective Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing mulitmodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centers. Methods and Materials Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative chemo-radiotherapy, surgery … Continued

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Results of intraoperative electron beam radiotherapy containing multimodality treatment for locally unresectable T4 rectal cancer: a pooled analysis of the Mayo Clinic Rochester and Catharina Hospital Eindhoven

Treatment Use

Electron IORT

Cancer Indication

Colorectal

Number of Patients

417

Summary/Conclusion

Overview The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality tratment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (CHE), both major referral centers for locally advanced rectal cancer. A … Continued

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2014 SICPRE Congress Best Abstracts – Aesthetic Evaluation in Oncoplastic and Conservative Breast Surgery: A Comparative Analysis

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

107

Summary/Conclusion

Background In conservative breast surgery, the achievement of a satisfactory cosmetic result could be challenging; oncoplastic techniques may be helpful in many cases. A comparative analysis was performed among 3 groups of patients undergoing oncoplastic techniques plus external radiation therapy or intraoperative radiotherapy (IORT) and breast conservative surgery plus external radiation therapy; long-term oncologic results … Continued

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Paly, J.J. et al., “Outcomes in a Multi-Institutional Cohort of Patients Treated with Intraoperative Radiation Therapy for Advanced or Recurrent Renal Cell Carcinoma.” (2014)

Treatment Use

Electron IORT

Cancer Indication

Genitourinary

Number of Patients

98

Summary/Conclusion

The outcomes for patients receiving IOERT in the setting of local recurrence compare favorably to similar cohorts treated by local resection alone suggesting the potential for improved DFS with IORT.

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Veronesi, U. et al., “Intraoperative Radiotherapy Versus External Radiotherapy for Early Breast Cancer (ELIOT): a Randomized Controlled Evidence Trial.” (2013)

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1305

Summary/Conclusion

Although the rate of IBTR was within pre-specified equivalence margin, the rate was significantly greater than with EBRT, and overall survival did not differ between the groups. Improved selection of patients should reduce the rate of IBTR with IOERT.

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Sophie Cai, et al., “Updated Long-Term Outcomes and Prognostic Factors for Patients With Unresectable Locally Advanced Pancreatic Cancer Treated With Intraoperative Radiotherapy at the Massachusetts General Hospital, 1978 to 2010” (2014)

Treatment Use

Electron IORT

Cancer Indication

Pancreatic

Number of Patients

194

Summary/Conclusion

Well-selected patients with LAPC with small tumors and low Charlson age-comorbidity indices can achieve good long-term survival outcomes with a treatment regimen that incorporates chemotherapy and IORT.

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