Tinkle, C. et al., “Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma.” (2015)

Treatment Use

Mobetron

Cancer Indication

Sarcoma

Number of Patients

26

Summary/Conclusion

This study demonstrates that incorporation of IORT as a component of multimodality management of patients with locally recurrent ESTS achieves high rates of local control and limb salvage with acceptable treatment morbidity and suggests that prior EBRT does not significantly influence disease control or toxicity. This technique offers a method of delivering focal therapy to achieve local control for the majority of patients who otherwise may require more radical surgical procedures.

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Phillippson, C. et al., “Early Invasive Cancer and Partial Intraoperative Electron Radiation Therapy of the Breast: Experience of the Jules Bordet Institute.” (2014)

Treatment Use

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

200

Summary/Conclusion

The preoperative diagnostic work-up must be comprehensive and the selection process must be rigorous for this therapeutic approach reserved for small ductal unifocal cancers. After 23.3 months median follow-up, the clinical results of IOERT for selected patients are encouraging for locoregional recurrence rate and toxicity rates. The satisfaction of our patients in terms of quality of life was extremely high.

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Ashman JB, et al. “Preoperative chemoradiation and IOERT for unresectable or borderline resectable pancreas cancer” (2013)

Treatment Use

Mobetron

Cancer Indication

Pancreatic

Number of Patients

31

Summary/Conclusion

Long term survival and disease control are achievable in select patients with borderline resectable or locally unresectable pancreas cancer when gross total surgical resection is achieved after preopCRT. Improvements in imaging continue to allow better selection of patients in whom gross total resection alone or plus IOERT may be feasible after preoperative treatment for initially unresectable or borderline resectable pancreas cancers.

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Leonardi, M.C. et al., “How do the ASTRO Consensus Statement Guidelines for the Application of Accelerated Partial Breast Irradiation Fit Intraoperative Radiotherapy? A Retrospective Analysis of Patients Treated at the European Institute of Oncology.” (2012)

Treatment Use

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1822

Summary/Conclusion

The 5-year rate of ipsilateral breast recurrence for ASTRO suitable, cautionary and unsuitable groups were 1.5%, 4.4% and 8.8% (p = 0.0003)…the ASTRO recommendations offer useful guidance to judge the appropriateness of APBI using ELIOT.

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Williams, C.P. et al., “Clinical Results of Intraoperative Radiation Therapy for Patients with Locally Recurrent and Advanced Tumors Having Colorectal Involvement.” (2008)

Treatment Use

Mobetron

Cancer Indication

Colorectal

Number of Patients

40

Summary/Conclusion

The introduction of IORT has allowed a selective treatment approach to locally advanced primary and recurrent neoplasms, which traditionally would have been deemed unresectable. Using IORT, extended resections may be avoided in selected high risk patients with low risk of local recurrence and minimal morbidity.

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