Meta-analysis of local recurrence of invasive breast cancer after electron intraoperative radiotherapy
Harness J, Shah C, Brooks E, Via C, Vicini F
The authors analyzed 13 different electron IORT APBI publications involving 1646 patients with follow-up times ranging from 17.7 months to 72 months by applying a binomial distribution to model the within-study variability and used a random effects model to estimate a pooled local recurrence rate (LRR). Using these models, they found a LRR of 0.02% per person month or a an adjusted 5-yerar local recurrence rate of 2.7%. The authors conclude that these findings support the recent ASTRO guidelines supporting the use of electron IORT APBI in low risk women.
Long-term outcomes using electron IORT APBI for early stage breast cancer: The Verona University Hospital experience
Cernusco NLV, Marciai N, de Liguoro M, Giri MG, Guariglia S, Lombardi D, Pellini F, Cavedon C, Pollini GP, Mazzarotto R
The U. of Verona reports on the long-term follow-up of 295 mostly ASTRO Suitable patients treated with electron APBI. With a median FU of 60 months (1-122 months), only 4 women (1.3%) experienced a true recurrence. There were no other ipsilateral recurrences. There were 2 women (0.67%) who developed distant metastases and 2 women (0.67%) who developed contralateral breast cancer. There were 21 patients (7.1%) who died, but
only 2 (0.67%) due to breast cancer. The authors conclude that, in selected low-risk patients, electron APBI can be delivered safely and with excellent results.
Multi-institution phase II trial of intraoperative electron beam radiotherapy boost at the time of breast conserving surgery with oncoplastic reconstruction in women with early-Stage breast cancer
Bazan JG, Stephens J, Terando A, Skoracki R, McElroy S, Sexton J, Gupta N, White J
A multi-institutional study is proposed testing cosmesis for electron IORT boost followed by oncoplastic reconstruction and 3 weeks of WBI. The Ohio State University is the principle investigating center and other U.S. institutions are invited to join. This study is being supported by IntraOp Medical.
Toxicity analysis of elderly breast cancer patients using different accelerated partial breast irradiation techniques
Jacobs DHM, Marijnen CAM, Speijer G, Straver M, Marinelli A, Merkus J, Roelofzzen EMA, Zwanenburg LAG, Fisscher U, Petoukhova AL, Mast ME, Koper P
The authors previously reported on cosmesis comparing IORT APBI with WBI. In that previous study, they noted that patients treated with IORT APBI had less asymmetry and high scores of good and excellent cosmesis. The current study will compare IORT APBI with other APBI techniques.