Intraoperative Radiation Therapy (IORT) in Pancreatic Cancer

Treatment Use

Electron IORT

Cancer Indication

Pancreatic

Number of Patients

Summary/Conclusion

Authors Robert Krempien and Falk Roeder Abstract Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy regimes led again to increased attention on the role of localized radiotherapy, since local tumor progression causes significant morbidity and mortality … Continued

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Total Neoadjuvant Therapy With FOLFIRINOX Followed by Individualized Chemoradiotherapy for Borderline Resectable Pancreatic Adenocarcinoma A Phase 2 Clinical Trial

Treatment Use

Mobetron

Cancer Indication

Pancreatic

Number of Patients

48

Summary/Conclusion

Authors Janet E. Murphy, MD, MPH;  Jennifer Y.Wo, MD; David P. Ryan, MD;  Wenqing Jiang, MS;  Beow Y. Yeap, ScD;  Lorraine C. Drapek, NP, PhD;  Lawrence S. Blaszkowsky, MD;  Eunice L. Kwak, MD, PhD;  Jill N. Allen, MD;  JeffreyW. Clark, MD;  Jason E. Faris, MD;  Andrew X. Zhu, MD, PhD;  Lipika Goyal, MD, MPhil;  Keith … Continued

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Survival and local control rates of triple-negative breast cancer patients treated with boost-IOERT during breast-conserving surgery

Treatment Use

Electron IORT

Mobetron

Cancer Indication

Breast (Boost)

Number of Patients

71

Summary/Conclusion

The purpose of this work was to retrospectively evaluate survival and local control rates of triple-negative breast cancer subtypes classified as five marker negative (5NP) and core basal (CB), respectively, after breast-conserving surgery and intraoperative boost radiotherapy with electrons (IOERT) followed by whole breast irradiation.

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Accelerated Partial Breast Irradiation: Update of an ASTRO Evidence-Based Consensus Statement

Treatment Use

Electron IORT

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1000

Summary/Conclusion

Recently, interest has also grown in intraoperative radiation therapy (IORT), which treats the partial breast with a single dose of radiation using either low-energy x-rays or electrons, most commonly delivered at the time of surgery. These different modalities are likely to have certain tradeoffs with regard to their effectiveness and toxicity profiles, although these tradeoffs have yet to be completely described in the existing literature.

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In vivo dosimetry with MOSFETs and GAFCHROMIC films during electron IORT for Accelerated Partial Breast Irradiation

Treatment Use

Electron IORT

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

47

Summary/Conclusion

Authors AnnaPetoukhova, IrisRüssel, JulienneNijst-Brouwers, Kovan Wingerden, Jaapvan Egmond, DaphneJacobs, AndreasMarinelli, Joostvan der Sijp, PeterKoper, HenkStruikmans  Purpose The purpose of this study was to compare the delivered dose to the expected intraoperative radiation therapy (IORT) dose with in vivo dosimetry. For IORT using electrons in accelerated partial breast irradiation, this is especially relevant since a high dose is delivered in a single fraction. Methods For … Continued

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