For decades, electron IORT has been used for locally advanced and recurrent cancers, achieving excellent clinical results in both local control and survival, especially in indications where it is often difficult to obtain clear surgical margins such as pancreatic cancer, colorectal cancers, head and neck cancers, GYN cancers, and sarcomas. The National Comprehensive Cancer Network (NCCN)http://www.nccn.org has recommended IORT with electrons as the treatment of choice for locally advanced and recurrent rectal cancer.
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