The GEC-ESTRO Phase III trial validates the oncologic concept of APBI. The results of the GEC-ESTRO phase III trial comparing APBI versus WBI are significant and potentially practice changing in that they indicate for the first time (in a large, well-designed, contemporary phase III trial with adequate follow-up) that the scientific concept of treating only the lumpectomy cavity (plus a proper margin) is just as effective and safe as treating the whole breast in selected patients with early stage breast cancer.
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