Proven Cancer Indications: Sarcoma

Summary/Conclusion

This study demonstrates that incorporation of IORT as a component of multimodality management of patients with locally recurrent ESTS achieves high rates of local control and limb salvage with acceptable treatment morbidity and suggests that prior EBRT does not significantly influence disease control or toxicity. This technique offers a method of delivering focal therapy to achieve local control for the majority of patients who otherwise may require more radical surgical procedures.

Summary/Conclusion

The combination of pre-operative radiation, surgical resection, and intraoperative radiation produce excellent local disease control for RPS.

Summary/Conclusion

Results from our study and review of the literature support the idea that IOERT is indeed a powerful tool in sterilizing local margins and improving local control and therefore disease-associated mortality.

Summary/Conclusion

For upper-extremity sarcoma, treatment including IOERT was associated with excellent LC, limb preservation and survival.

Summary/Conclusion

In selected patients, IOERT results in excellent local control and survival, with acceptable morbidity….IOERT in combination with EBRT seems to be able to compensate for minimal residual disease.

Summary/Conclusion

For patients with soft tissue sarcomas of the extremities, IORT used as a boost to EBRT provides excellent local control, with limited toxicities.