In vivo dosimetry with MOSFETs and GAFCHROMIC films during electron IORT for Accelerated Partial Breast Irradiation

Treatment Use

Electron IORT

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

47

Summary/Conclusion

Authors AnnaPetoukhova, IrisRüssel, JulienneNijst-Brouwers, Kovan Wingerden, Jaapvan Egmond, DaphneJacobs, AndreasMarinelli, Joostvan der Sijp, PeterKoper, HenkStruikmans  Purpose The purpose of this study was to compare the delivered dose to the expected intraoperative radiation therapy (IORT) dose with in vivo dosimetry. For IORT using electrons in accelerated partial breast irradiation, this is especially relevant since a high dose is delivered in a single fraction. Methods For … Continued

Read More

Tinkle, C. et al., “Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma.” (2015)

Treatment Use

Mobetron

Cancer Indication

Sarcoma

Number of Patients

26

Summary/Conclusion

This study demonstrates that incorporation of IORT as a component of multimodality management of patients with locally recurrent ESTS achieves high rates of local control and limb salvage with acceptable treatment morbidity and suggests that prior EBRT does not significantly influence disease control or toxicity. This technique offers a method of delivering focal therapy to achieve local control for the majority of patients who otherwise may require more radical surgical procedures.

Read More

Phillippson, C. et al., “Early Invasive Cancer and Partial Intraoperative Electron Radiation Therapy of the Breast: Experience of the Jules Bordet Institute.” (2014)

Treatment Use

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

200

Summary/Conclusion

The preoperative diagnostic work-up must be comprehensive and the selection process must be rigorous for this therapeutic approach reserved for small ductal unifocal cancers. After 23.3 months median follow-up, the clinical results of IOERT for selected patients are encouraging for locoregional recurrence rate and toxicity rates. The satisfaction of our patients in terms of quality of life was extremely high.

Read More

Ashman JB, et al. “Preoperative chemoradiation and IOERT for unresectable or borderline resectable pancreas cancer” (2013)

Treatment Use

Mobetron

Cancer Indication

Pancreatic

Number of Patients

31

Summary/Conclusion

Long term survival and disease control are achievable in select patients with borderline resectable or locally unresectable pancreas cancer when gross total surgical resection is achieved after preopCRT. Improvements in imaging continue to allow better selection of patients in whom gross total resection alone or plus IOERT may be feasible after preoperative treatment for initially unresectable or borderline resectable pancreas cancers.

Read More