IORT with Electrons in Breast Cancer: 10-Year Results

Treatment Use

Electron IORT

Cancer Indication

Breast (Boost)

Number of Patients

770

Summary/Conclusion

This study provides 10-year outcome data of 770 stage I through III breast cancer patients who received intraoperative electron radiation therapy (IOERT) as a tumor bed boost preceding whole breast irradiation. After a median follow-up period of 121 months, 21 in-breast recurrences (2.7%) occurred with triple-negative and HER2fl subtypes as negative predictors. As confirmed in long-term follow-up, IOERT has been demonstrated to be a viable boost strategy in any risk constellation.

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Survival and local control rates of triple-negative breast cancer patients treated with boost-IOERT during breast-conserving surgery

Treatment Use

Electron IORT

Mobetron

Cancer Indication

Breast (Boost)

Number of Patients

71

Summary/Conclusion

The purpose of this work was to retrospectively evaluate survival and local control rates of triple-negative breast cancer subtypes classified as five marker negative (5NP) and core basal (CB), respectively, after breast-conserving surgery and intraoperative boost radiotherapy with electrons (IOERT) followed by whole breast irradiation.

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Reitsamer, R. et al., “The Salzburg concept of intraoperative radiotherapy for breast cancer: Results and considerations.” (2006)

Treatment Use

Electron IORT

Cancer Indication

Breast (Boost)

Number of Patients

378

Summary/Conclusion

Immediate IORT-boost and whole breast irradiation yields excellent local control at 5 years, and was associated with a statistically significant decreased rate of IBTR compared with a similar cohort of patients treated with whole breast irradiation and conventional electron boost.

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