Kondo, T. et al., “Intraoperative Radiotherapy Combined with Posterior Decompression and Stabilization for Non-Ambulatory Paralytic Patients due to Spinal Metastasis.” (2008)

Treatment Use

Electron IORT

Cancer Indication

Spinal Metastases

Number of Patients

107

Summary/Conclusion

IORT for spinal cord compression caused by metastatic spinal tumors achieved a good post-operative ambulatory rate (80%) regardless of the cancer type or presence or absence of previous EBRT, thereby revealing its usefulness.

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Jaske G., et al., “IORT and External Beam Irradiation (EBI) in Clinical Stage I-II NSCLC Patients with Severely Compromised Pulmonary Function: A 52-Patient Single-institutional Experience.” (2007)

Treatment Use

Electron IORT

Cancer Indication

Lung

Number of Patients

52

Summary/Conclusion

The use of IORT to deliver high single fraction doses precisely limited to the tumor and the possibility to tailor subsequent moderate-dose EBRT according to the spread of the disease offers a potentially curative therapy in patients who are unable to undergo radical surgery or radical EBRT due to their severe functional impairment.

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Reitsamer, R. et al., “The Salzburg concept of intraoperative radiotherapy for breast cancer: Results and considerations.” (2006)

Treatment Use

Electron IORT

Cancer Indication

Breast (Boost)

Number of Patients

378

Summary/Conclusion

Immediate IORT-boost and whole breast irradiation yields excellent local control at 5 years, and was associated with a statistically significant decreased rate of IBTR compared with a similar cohort of patients treated with whole breast irradiation and conventional electron boost.

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