Treatment Use: Electron IORT

Summary/Conclusion

APBI using a single dose of IOERT can be delivered safely in women with early, low-risk breast cancer in carefully selected patients.

Summary/Conclusion

In patients with recurrent or advanced urothelial carcinoma, this multimodality approach yielded a low rate of recurrence with an acceptable toxicity.

Summary/Conclusion

For upper-extremity sarcoma, treatment including IOERT was associated with excellent LC, limb preservation and survival.

Summary/Conclusion

IOERT followed by adjuvant chemoradiotherapy after D2 gastrectomy is an efficacious and well tolerated treatment for patients with locally advanced gastric adenocarcinoma. It significantly improves locoregional control and marginally improves disease free survival.

Summary/Conclusion

Combined modality therapy with EBRT, surgery and IOERT is an option for the treatment of localized recurrent ovarian cancer, with acceptable rates of in-field failure and toxicity. Durable disease control is possible in select women treated with this regimen.

Summary/Conclusion

IORT results in effective local disease control at acceptable levels of toxicity. Our results support the
initiation of a phase III trial comparing outcomes for patients with cervical metastasis treated with or without IORT.

Summary/Conclusion

IORT results in effective local disease control at acceptable levels of toxicity and should be considered for patients with primary or recurrent cancer of the parotid gland.

Summary/Conclusion

In patients with LR recurrent or LR advanced primary RCC, a multimodality approach of perioperative EBRT, maximum surgical resection and IOERT yielded encouraging results…With mature follow-up, this treatment approach was associated with a low rate of LR recurrence, acceptable toxicity, and long-term survival in a significant number of patients.

Summary/Conclusion

Long-term survival and disease control was achievable in patients with locally recurrent colorectal cancer…curative- intent, combined-modality therapy that includes IOERT is warranted in this high-risk population.

Summary/Conclusion

Multimodality treatment is effective in prevention of local recurrence in LARC. IORT application to the area most at risk is feasible and seems effective in the prevention of local recurrence.