Proven Cancer Indications: Colorectal

Summary/Conclusion

Objective Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing mulitmodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centers. Methods and Materials Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative chemo-radiotherapy, surgery … Continued

Summary/Conclusion

Overview The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality tratment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (CHE), both major referral centers for locally advanced rectal cancer. A … Continued

Summary/Conclusion

Long-term survival and disease control was achievable in patients with locally recurrent colorectal cancer…curative- intent, combined-modality therapy that includes IOERT is warranted in this high-risk population.

Summary/Conclusion

Multimodality treatment is effective in prevention of local recurrence in LARC. IORT application to the area most at risk is feasible and seems effective in the prevention of local recurrence.

Summary/Conclusion

The introduction of IORT has allowed a selective treatment approach to locally advanced primary and recurrent neoplasms, which traditionally would have been deemed unresectable. Using IORT, extended resections may be avoided in selected high risk patients with low risk of local recurrence and minimal morbidity.