Results of a pooled analysis of IOERT containing multimodality treatment for locally recurrent rectal cancer: Results of 565 patients of two major treatment centers

Treatment Use

Electron IORT

Cancer Indication

Colorectal

Number of Patients

565

Summary/Conclusion

Objective Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing mulitmodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centers. Methods and Materials Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative chemo-radiotherapy, surgery … Continued

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Results of intraoperative electron beam radiotherapy containing multimodality treatment for locally unresectable T4 rectal cancer: a pooled analysis of the Mayo Clinic Rochester and Catharina Hospital Eindhoven

Treatment Use

Electron IORT

Cancer Indication

Colorectal

Number of Patients

417

Summary/Conclusion

Overview The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality tratment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (CHE), both major referral centers for locally advanced rectal cancer. A … Continued

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2014 SICPRE Congress Best Abstracts – Aesthetic Evaluation in Oncoplastic and Conservative Breast Surgery: A Comparative Analysis

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

107

Summary/Conclusion

Background In conservative breast surgery, the achievement of a satisfactory cosmetic result could be challenging; oncoplastic techniques may be helpful in many cases. A comparative analysis was performed among 3 groups of patients undergoing oncoplastic techniques plus external radiation therapy or intraoperative radiotherapy (IORT) and breast conservative surgery plus external radiation therapy; long-term oncologic results … Continued

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Paly, J.J. et al., “Outcomes in a Multi-Institutional Cohort of Patients Treated with Intraoperative Radiation Therapy for Advanced or Recurrent Renal Cell Carcinoma.” (2014)

Treatment Use

Electron IORT

Cancer Indication

Genitourinary

Number of Patients

98

Summary/Conclusion

The outcomes for patients receiving IOERT in the setting of local recurrence compare favorably to similar cohorts treated by local resection alone suggesting the potential for improved DFS with IORT.

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Veronesi, U. et al., “Intraoperative Radiotherapy Versus External Radiotherapy for Early Breast Cancer (ELIOT): a Randomized Controlled Evidence Trial.” (2013)

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1305

Summary/Conclusion

Although the rate of IBTR was within pre-specified equivalence margin, the rate was significantly greater than with EBRT, and overall survival did not differ between the groups. Improved selection of patients should reduce the rate of IBTR with IOERT.

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Sophie Cai, et al., “Updated Long-Term Outcomes and Prognostic Factors for Patients With Unresectable Locally Advanced Pancreatic Cancer Treated With Intraoperative Radiotherapy at the Massachusetts General Hospital, 1978 to 2010” (2014)

Treatment Use

Electron IORT

Cancer Indication

Pancreatic

Number of Patients

194

Summary/Conclusion

Well-selected patients with LAPC with small tumors and low Charlson age-comorbidity indices can achieve good long-term survival outcomes with a treatment regimen that incorporates chemotherapy and IORT.

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Tamaki, Y. et al., “Efficacy of Intraoperative Radiotherapy Targeted to the Abdominal Lymph Node Area in Patients with Esophageal Carcinoma.” (2012)

Treatment Use

Electron IORT

Cancer Indication

Esophageal

Number of Patients

72

Summary/Conclusion

Both univariate and multivariate analysis revealed the survival rate was significantly higher in patients that received IORT than in those that did not (p = 0.026). There were no perioperative complications attributed to IORT. IORT for esophageal carcinoma will likely be effective for patients with a primary lesion in the lower thoracic or abdominal esophagus, or with a long lesion.

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