Treatment Use: Electron IORT

Summary/Conclusion

Objective Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing mulitmodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centers. Methods and Materials Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative chemo-radiotherapy, surgery … Continued

Summary/Conclusion

Overview The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality tratment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (CHE), both major referral centers for locally advanced rectal cancer. A … Continued

Summary/Conclusion

Background In conservative breast surgery, the achievement of a satisfactory cosmetic result could be challenging; oncoplastic techniques may be helpful in many cases. A comparative analysis was performed among 3 groups of patients undergoing oncoplastic techniques plus external radiation therapy or intraoperative radiotherapy (IORT) and breast conservative surgery plus external radiation therapy; long-term oncologic results … Continued

Summary/Conclusion

The outcomes for patients receiving IOERT in the setting of local recurrence compare favorably to similar cohorts treated by local resection alone suggesting the potential for improved DFS with IORT.

Summary/Conclusion

Although the rate of IBTR was within pre-specified equivalence margin, the rate was significantly greater than with EBRT, and overall survival did not differ between the groups. Improved selection of patients should reduce the rate of IBTR with IOERT.

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Well-selected patients with LAPC with small tumors and low Charlson age-comorbidity indices can achieve good long-term survival outcomes with a treatment regimen that incorporates chemotherapy and IORT.

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In all risk groups, a 10 Gy IOERT boost prior to WBI provided outstanding local control rates, comparing favorably to all trials with similar length of follow-up.

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Long-term survival is possible with combined modality therapy including IOERT for advanced cervical cancer.

Summary/Conclusion

IOERT is a feasible technique and can be viewed as a tool in the treatment of newly diagnosed and recurrent brain gliomas.

Summary/Conclusion

Both univariate and multivariate analysis revealed the survival rate was significantly higher in patients that received IORT than in those that did not (p = 0.026). There were no perioperative complications attributed to IORT. IORT for esophageal carcinoma will likely be effective for patients with a primary lesion in the lower thoracic or abdominal esophagus, or with a long lesion.