Treatment Use: Mobetron

Summary/Conclusion

Long term survival and disease control are achievable in select patients with borderline resectable or locally unresectable pancreas cancer when gross total surgical resection is achieved after preopCRT. Improvements in imaging continue to allow better selection of patients in whom gross total resection alone or plus IOERT may be feasible after preoperative treatment for initially unresectable or borderline resectable pancreas cancers.

Summary/Conclusion

IOERT boost during surgery not only enables good local control without geometric miss of the tumor, but also delivers good cosmetic effect after therapy.

Summary/Conclusion

IOERT resulted in a reduction of treatment time, was not associated with additional toxicity or change in the acute toxicity profile, and is a feasible treatment option in a community setting.

Summary/Conclusion

APBI using a single dose of IOERT can be delivered safely in women with early, low-risk breast cancer in carefully selected patients.

Summary/Conclusion

The 5-year rate of ipsilateral breast recurrence for ASTRO suitable, cautionary and unsuitable groups were 1.5%, 4.4% and 8.8% (p = 0.0003)…the ASTRO recommendations offer useful guidance to judge the appropriateness of APBI using ELIOT.

Summary/Conclusion

The introduction of IORT has allowed a selective treatment approach to locally advanced primary and recurrent neoplasms, which traditionally would have been deemed unresectable. Using IORT, extended resections may be avoided in selected high risk patients with low risk of local recurrence and minimal morbidity.

Summary/Conclusion

IORT at the time of primary resection offers effective local control in patients with high-risk neuroblastoma. Compared to historical controls, IORT achieved comparable control and survival rates while avoiding many side effects associated with external beam radiotherapy in young children.

Summary/Conclusion

IORT results in effective disease control with acceptable toxicity and should be considered for selected patients with recurrent or persistent cancers of the head and neck.

Summary/Conclusion

For patients with soft tissue sarcomas of the extremities, IORT used as a boost to EBRT provides excellent local control, with limited toxicities.

Summary/Conclusion

Selected patients with isolated local recurrence in the renal fossa may have favorable and durable outcomes following surgical resection and adjuvant IORT for isolated renal fossa recurrence following radical nephrectomy.