Summary/Conclusion
From this joint analysis emerges the fact that preoperative radiotherapy increases the effects of IORT in terms of local control and overall survival.
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January 1, 2008
Kondo, T. et al., “Intraoperative Radiotherapy Combined with Posterior Decompression and Stabilization for Non-Ambulatory Paralytic Patients due to Spinal Metastasis.” (2008)
Summary/Conclusion
IORT for spinal cord compression caused by metastatic spinal tumors achieved a good post-operative ambulatory rate (80%) regardless of the cancer type or presence or absence of previous EBRT, thereby revealing its usefulness.
Read MoreDecember 4, 2007
Williams, C.P. et al., “Clinical Results of Intraoperative Radiation Therapy for Patients with Locally Recurrent and Advanced Tumors Having Colorectal Involvement.” (2008)
Summary/Conclusion
The introduction of IORT has allowed a selective treatment approach to locally advanced primary and recurrent neoplasms, which traditionally would have been deemed unresectable. Using IORT, extended resections may be avoided in selected high risk patients with low risk of local recurrence and minimal morbidity.
Read MoreApril 4, 2007
Gillis, A. et al. “Long-term Outcomes and Toxicities of Intraoperative Radiotherapy for High-Risk Neuroblastoma.” (2007)
Summary/Conclusion
IORT at the time of primary resection offers effective local control in patients with high-risk neuroblastoma. Compared to historical controls, IORT achieved comparable control and survival rates while avoiding many side effects associated with external beam radiotherapy in young children.
Read MoreJanuary 1, 2007
Jaske G., et al., “IORT and External Beam Irradiation (EBI) in Clinical Stage I-II NSCLC Patients with Severely Compromised Pulmonary Function: A 52-Patient Single-institutional Experience.” (2007)
Summary/Conclusion
The use of IORT to deliver high single fraction doses precisely limited to the tumor and the possibility to tailor subsequent moderate-dose EBRT according to the spread of the disease offers a potentially curative therapy in patients who are unable to undergo radical surgery or radical EBRT due to their severe functional impairment.
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