Intraoperative Radiotherapy in the Era of Intensive Neoadjuvant Chemotherapy and Chemoradiotherapy for Pancreatic Adenocarcinoma

Treatment Use

Electron IORT

Cancer Indication

Pancreatic

Number of Patients

68

Summary/Conclusion

Objectives Improved outcomes with FOLFIRINOX or gemcitabine with nab-paclitaxel in the treatment of metastatic pancreatic adenocarcinoma (PDAC) have prompted incorporation of these regimens into neoadjuvant treatment of locally advanced unresectable PDAC. Whereas some patients remain unresectable on surgical exploration, others are able to undergo resection after intensive neoadjuvant treatment. We evaluated outcomes and toxicity associated … Continued

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Results of a pooled analysis of IOERT containing multimodality treatment for locally recurrent rectal cancer: Results of 565 patients of two major treatment centers

Treatment Use

Electron IORT

Cancer Indication

Colorectal

Number of Patients

565

Summary/Conclusion

Objective Aim of this study is analysing the pooled results of Intra-Operative Electron beam Radiotherapy (IOERT) containing mulitmodality treatment of locally recurrent rectal cancer (LRRC) of two major treatment centers. Methods and Materials Five hundred sixty five patients with LRRC who underwent multimodality-treatment up to 2010 were studied. The preferred treatment was preoperative chemo-radiotherapy, surgery … Continued

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Results of intraoperative electron beam radiotherapy containing multimodality treatment for locally unresectable T4 rectal cancer: a pooled analysis of the Mayo Clinic Rochester and Catharina Hospital Eindhoven

Treatment Use

Electron IORT

Cancer Indication

Colorectal

Number of Patients

417

Summary/Conclusion

Overview The aim of this study is to analyse the pooled results of intraoperative electron beam radiotherapy (IOERT) containing multimodality tratment of locally advanced T4 rectal cancer, initially unresectable for cure, from the Mayo Clinic, Rochester, USA (MCR) and Catharina Hospital, Eindhoven, The Netherlands (CHE), both major referral centers for locally advanced rectal cancer. A … Continued

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Tinkle, C. et al., “Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma.” (2015)

Treatment Use

Mobetron

Cancer Indication

Sarcoma

Number of Patients

26

Summary/Conclusion

This study demonstrates that incorporation of IORT as a component of multimodality management of patients with locally recurrent ESTS achieves high rates of local control and limb salvage with acceptable treatment morbidity and suggests that prior EBRT does not significantly influence disease control or toxicity. This technique offers a method of delivering focal therapy to achieve local control for the majority of patients who otherwise may require more radical surgical procedures.

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2014 SICPRE Congress Best Abstracts – Aesthetic Evaluation in Oncoplastic and Conservative Breast Surgery: A Comparative Analysis

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

107

Summary/Conclusion

Background In conservative breast surgery, the achievement of a satisfactory cosmetic result could be challenging; oncoplastic techniques may be helpful in many cases. A comparative analysis was performed among 3 groups of patients undergoing oncoplastic techniques plus external radiation therapy or intraoperative radiotherapy (IORT) and breast conservative surgery plus external radiation therapy; long-term oncologic results … Continued

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