Clinical Evidence

Summary/Conclusion

Well-selected patients with LAPC with small tumors and low Charlson age-comorbidity indices can achieve good long-term survival outcomes with a treatment regimen that incorporates chemotherapy and IORT.

Summary/Conclusion

In all risk groups, a 10 Gy IOERT boost prior to WBI provided outstanding local control rates, comparing favorably to all trials with similar length of follow-up.

Summary/Conclusion

Results from our study and review of the literature support the idea that IOERT is indeed a powerful tool in sterilizing local margins and improving local control and therefore disease-associated mortality.

Summary/Conclusion

Long term survival and disease control are achievable in select patients with borderline resectable or locally unresectable pancreas cancer when gross total surgical resection is achieved after preopCRT. Improvements in imaging continue to allow better selection of patients in whom gross total resection alone or plus IOERT may be feasible after preoperative treatment for initially unresectable or borderline resectable pancreas cancers.

Summary/Conclusion

Long-term survival is possible with combined modality therapy including IOERT for advanced cervical cancer.