Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Treatment Use

FLASH-RT

Cancer Indication

Electron-beam FLASH

Number of Patients

0

Summary/Conclusion

Pulsed irradiation (FLASH) was performed using the 4.5 MeV linear electron accelerator (LINAC) described in (34). The system allows exposure of cells or animals to a single submicrosecond pulse, to any sequence of pulses, or to split-dose irradiation with an interval between fractions ranging from fractions of seconds to a few minutes.

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Phillippson, C. et al., “Early Invasive Cancer and Partial Intraoperative Electron Radiation Therapy of the Breast: Experience of the Jules Bordet Institute.” (2014)

Treatment Use

Mobetron

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

200

Summary/Conclusion

The preoperative diagnostic work-up must be comprehensive and the selection process must be rigorous for this therapeutic approach reserved for small ductal unifocal cancers. After 23.3 months median follow-up, the clinical results of IOERT for selected patients are encouraging for locoregional recurrence rate and toxicity rates. The satisfaction of our patients in terms of quality of life was extremely high.

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Paly, J.J. et al., “Outcomes in a Multi-Institutional Cohort of Patients Treated with Intraoperative Radiation Therapy for Advanced or Recurrent Renal Cell Carcinoma.” (2014)

Treatment Use

Electron IORT

Cancer Indication

Genitourinary

Number of Patients

98

Summary/Conclusion

The outcomes for patients receiving IOERT in the setting of local recurrence compare favorably to similar cohorts treated by local resection alone suggesting the potential for improved DFS with IORT.

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Veronesi, U. et al., “Intraoperative Radiotherapy Versus External Radiotherapy for Early Breast Cancer (ELIOT): a Randomized Controlled Evidence Trial.” (2013)

Treatment Use

Electron IORT

Cancer Indication

Breast (Single-Fraction APBI)

Number of Patients

1305

Summary/Conclusion

Although the rate of IBTR was within pre-specified equivalence margin, the rate was significantly greater than with EBRT, and overall survival did not differ between the groups. Improved selection of patients should reduce the rate of IBTR with IOERT.

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